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Interestingly, although ROS can drive tumor progression, they also have the potential to induce apoptosis when levels become excessively high, highlighting the dual nature of ROS in melanoma pathophysiology 121,122

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Effective method for drug injection into subcutaneous tissue

P53 can induce ferroptosis and consequently tumor cell death by inhibiting GSH synthesis through the downregulation of SLC7A11 expression (57)

Unlike oral supplements, which often have poor bioavailability due to breakdown in the digestive tract, intramuscular (IM) or intravenous (IV) Glutathione injections ensure 100% absorption directly into the bloodstream

Three groups of mice were used: B6 (WT), humanized mice expressing human canonical HBB (with Cys93 only), and humanized mice expressing HBB C93A (Cys93Ala)